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Participants were allocated in a 21:3:3:7 ratio to weekly injections of one of four regimens: fixed-dose cagrilintide 2.4 mg plus semaglutide 2.4 mg, semaglutide alone, cagrilintide alone, or placebo

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While generally considered safe, semaglutide may be less effective for patients with MASH who dont also have obesity or diabetes, poses specific risks for older adults (like muscle loss and side effects), and isnt approved for children or teens or for those navigating severe complications like cirrhosis

Combination therapy may include topical depigmenting agents, retinoids, chemical peels, and strict sun protection