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Despite significant advances in understanding GLP-1RAs' mechanisms of action and their application in diabetes treatment, several critical knowledge gaps persist

There is currently no specific contraindication to using GLP-1 receptor agonists in people with Crohn's disease, but this decision requires careful individualised assessment

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Various mechanisms have been theorized to describe how dual agonism, as GLP-1 RA, could directly reduce triglycerides hepatocyte storage, lipogenesis and improving hepatic glucose metabolism (96) and promoting lipolysis and fatty acid oxidation (97)