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SGLT-2, in contrast, is a high-capacity, low-affinity transporter expressed primarily in the kidney and is predominantly located in the S1 (early) segment of the proximal tubule

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Once I lost the first huge chunk of weight, it was easier for me to move around

Unsaturated VPA metabolites (4-en-VPA and 2, 4-dien-VPA) are potent inducers of microvesicular steatosis in rats, whereas VPA itself failed to induce discernible liver lesions at near lethal doses [60]