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Conversely, other influences can lead to an increased sensitivity to noxious stimuli

Here, we propose SAGE-DM (Senescence-Associated Gluco-Endocrinopathy Diabetes Mellitus), a novel conceptual framework that extends the definition of so-called type 4 diabetes. SAGE-DM is characterised by insulin resistance and glucose dysregulation in lean or olders with sarcopenic obesity individuals, arising from endocrine senescence, chronic low-grade inflammation, and immunemetabolic crosstalk

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however, large servings may cause gastrointestinal discomfort and benign beeturia

doi: 10.1016/0190-9622(95)90073-x 67 WickMRElenitsasRKimJKossardR