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Source: Jastreboff et al., NEJM 2023

The PPP provides reduced nicotinamide adenine dinucleotide phosphate (NADPH), which fuels NADPH oxidase activity responsible for the bulk of ROS generation critical to microbial killing

By treating both of those conditions, GLP-1s also reduce the risk of kidney problems

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The pharmacological blockage of SGLT-1 with phloridzin, in a rat small intestine perfused system, results in just a halved secretion of GIP, GLP-1, or PYY, and the addition of phloretin, a GLUT2 inhibitor, brings these values down to basal levels