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[28] The two primary metabolic routes that convert dopamine into HVA are: [29] Dopamine DOPAL DOPAC HVA catalyzed by MAO, ALDH, and COMT respectively Dopamine 3-Methoxytyramine HVA catalyzed by COMT and MAO+ALDH respectively In clinical research on schizophrenia, measurements of homovanillic acid in plasma have been used to estimate levels of dopamine activity in the brain

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This mechanism offers a complementary pathway to GLP-1 agonists for metabolic research