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The only untoward consequence of alkaptonuria is ochronosis (bluish-black discoloration of the tissues) and arthritis of indeterminate etiology

In combination with immunological cross-reactivities and functional data they formed the basis of an evolutionary tree (Figure 1 shows a phylogram based on the aminoacid sequences of the 18 distinct gene products occurring as soluble dimeric proteins in humans

Each butterfly needle is attached to transparent tubing and a connector

It is resistant to digestion and reaches the large intestine, where it serves as an energy source for beneficial bacteria such as Bifidobacterium and Lactobacillus (131, 132)