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Drug repurposing by siderophore conjugation: synthesis and biological evaluation of siderophore-methotrexate conjugates as antibiotics

DOI: 10.1007/s00425-002-0902-6 100

This dual-pathway combination allows investigators to study GLP-1R/GIPR/GCGR triple incretin agonism together with long-acting amylin-pathway modulation in experimental models of energy balance, appetite signaling, and metabolic regulation

The concerns surrounding hormone therapy extend beyond CVD and breast cancer, as it has also been correlated with an increased risk of venous thromboembolism, overall mortality, and cancer-related deaths (164, 165)