According to numerous retrospective case-controlled studies, moderate increases in plasma homocysteine, which can be precisely quantitated by high performance liquid chromatography (HPLC), raise the risk for cardiovascular disease 2-fold, after adjusting for classic risk factors
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4 Hypothesis of the gut microbiota-ferroptosis axis in OA pathogenesis 4.1 Gut microbiota and abnormal iron metabolism synergistically promote joint ferroptosis 4.1.1 Gut microbiota promotes ferroptosis via hepcidin-FPN1 axis and FTN-mediated iron overload The gut microbiota modify systemic iron homeostasis through the modulating ability of microbiota to regulate the synthesis of hepatic hepcidin, an effect the subject of intense investigation
The proto-oncogene cMyc up-regulates glutamine breakdown through transcriptional activation of the GLS and SLC1A5 genes