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PMID: 128 YoshidaN.ImadaH.KunugitaN.NorimuraT
Li W, Nie S, Xie M, Chen Y, Li C, Zhang H
Aust Fam Physician
At a glance Drug / alendronate (Fosamax), oral bisphosphonate for osteoporosis Supplement / glutathione, endogenous antioxidant tripeptide (glycine-cysteine-glutamate) Known direct interaction / none reported in peer-reviewed pharmacokinetic studies as of 2025 Primary risk / indirect: oral glutathione taken near alendronate may worsen already-poor bisphosphonate absorption Alendronate fasting bioavailability / approximately 0.6% of oral dose reaches systemic circulation Recommended separation window / minimum 30 minutes before or 2 hours after alendronate dosing IV or liposomal glutathione / no chelation data available
A pilot BarSeq experiment (see below for the method) sequenced on a MiSeq with reagent kit v2 (Gnome Qubec, Montral, Canada) using the first collected subpool confirmed it was highly diverse as expected
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