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Recently, seminal papers in the field have demonstrated that activation of dendritic cells with the TLR4 agonist lipopolysaccharide (LPS) has profound metabolic consequences that may correlate to altered immune function [1719]

62 From statistical models to ML: foundations in bulk and single-cell analysis Early statistical methods such as CellCODE introduced latent variable models for deconvoluting cell-type-specific signals from heterogeneous bulk RNA-seq data without requiring explicit cell proportion measurements

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