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These include the presence of BMLs, fibrosis, microfractures, and abnormal vascularization, which strongly correlate with pain severity and structural disease progression (Seref-Ferlengez et al., 2015)

However, emerging clinical research is shedding light on the profound cellular dysfunctionsspecifically oxidative stress and mitochondrial failurethat drive these conditions

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Pyridoxal 5'-phosphate in cerebrospinal fluid