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Although prospective studies specifically targeting PCOS + MASLD with pregnancy outcomes as the primary endpoint are currently lacking, a robust inference can be drawn based on the pathophysiological framework of MASLD and evidence from the general population: proactively identifying and reducing MASLD and ectopic fat load prior to pregnancy may be a key step in improving both periconception outcomes and long-term prognosis (68, 76)

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Our results indicate that DDA complexes with GSH-AuNCs and readily induces their complete transfer to chloroform or dichloromethane (typical solvents to prepare PLGA nanoparticles) as well as to other hydrophobic solvents (hexane and toluene) as shown in Fig

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Front Biosci (Schol Ed) 4:722748 Mats JM, Segura JA, Campos-Sandoval JA et al (2009) Glutamine homeostasis and mitochondrial dynamics

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Its akin to pouring more water into a bucket with a hole in it, without plugging up the leak

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