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However, independent human evidence confirming meaningful anti-aging effects is extremely limited

A good example is a review published in 2003 in Endocrine Reviews , in which the authors note the importance of [growth hormone] and IGF systems in normal skin homeostasis. They specifically mention the role that growth hormone plays in collagen synthesis and the effect that IGF has on skin cell proliferation

The work of Bock-Marquette and collaborators (2004) demonstrated the cardioprotective effect of thymosin beta-4 in a murine model of myocardial ischemia, a finding confirmed by several independent teams

however, side effects such as myopathy, gallstones, and drugdrug interactions (such as those caused by gemfibrozil) must be considered (195)

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