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Some individuals may experience an increase in appetite, while others may experience a decrease or no noticeable change

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If intranasal retatrutide achieves preferential brain delivery, lower systemic doses could potentially produce central appetite suppression effects comparable to higher subcutaneous doses

In summary, pioglitazone and vitamin E are now recommended as pharmacotherapies for biopsy-proven NASH patients with and without diabetes, respectively, although long-term efficacy or safety should be established (Table 1) [5,6,7,8]

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