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Ishihara T, Kubota T, Choi T, Higaki M

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Investigators have also noted that the pronounced appetite-stimulating effect of MK-677 an on-target consequence of ghrelin receptor agonism in hypothalamic appetite circuits complicates body composition endpoints in metabolic studies, as caloric intake must be carefully controlled to isolate GH-axis-mediated changes from orexigenic-driven weight gain

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While the side effects were manageable in the trial, they are still important safety considerations

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That distinction is the single most important thing to carry away from the regulatory picture

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