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A systematic review and meta-analysis of trials involving NAC supplementation reported significant increases in antioxidant markers including glutathione, catalase, and Total Antioxidant Capacity

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These users report appreciating treatment benefits while active but watching improvements gradually fade over months post-discontinuation, with timeline showing first 2 months maintaining most benefits creating initial optimism, months 2-4 showing noticeable decline returning toward baseline, months 4-8 continuing regression approaching pre-treatment status, and stabilization occurring 60-80% back toward original baseline with only modest long-term improvement retention

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