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10.1111/1541-4337.12539 [DOI] [PubMed] [Google Scholar] Ben-Meir A., Burstein E., Borrego-Alvarez A., Chong J., Wong E., Yavorska T., et al

Glutathione peroxidase (GPX) role in oxidative stress and its interaction with superoxide dismutase (SOD) The SOD gene locus resides on chromosome 21 and as a consequence of gene dosage excess, SOD activity has been shown to be increased by about 50% in all tissues of patients with Down syndrome (Brooksbank & Balzas, 1983

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In the presence of metal ions, either from the parotid glands or directly from cigarette smoke, H 2 O 2 initiates the previously described Fenton and Haber Weiss reactions, leading to the formation of OH (Nagler et al., 1997)