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Red-flag symptoms such as severe abdominal pain, persistent vomiting, or jaundice require immediate cessation and urgent medical attention
Both medications require consistent use, adherence to proper dosing schedules, and a commitment to healthy lifestyle changes
Tirzepatide, which acts on both GIP and GLP-1 receptors, appears to have a somewhat more favorable GI tolerability profile, possibly because GIP receptor activation partially counteracts the nausea-inducing effects of GLP-1 agonism
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