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Individual Response Factors and Biomarker Context Response to tirzepatide dosing varies significantly between individuals due to differences in metabolic health, insulin sensitivity, and genetic variation in GLP-1 receptor and GIPR signaling

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Tirzepatide is a novel investigational once-weekly dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist that integrates the actions of the GIP and GLP-1 incretins into a single molecule, representing a new class of medicines being studied for the treatment of type 2 diabetes

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"Polyendocrine metabolic ovarian syndrome, the new name for polycystic ovary syndrome: a multistep global consensus process"