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Cycling protocols with appropriate off-periods are recommended to maintain sensitivity and reduce potential cumulative effects

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Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults The comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults were recently investigated in a well-conducted systematic review and network meta-analysis published by Yildiz et al [7], comprising 101 randomised controlled trials covering 20,081 study participants and 68 medications and placebo