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People who do not achieve a reduction in blood glucose to a target threshold, despite diet and lifestyle modifications and use of metformin, require treatment intensification with an additional glucose-lowering medication

If lower doses are working or if there are side effects it makes sense to stay longer at the lower doses however as you can see in the study above, the 25 mg dose is where the full treatment effect was noted

NF-B activation helps ectopic lesions survive, drives the inflammatory cytokine environment in the peritoneal cavity, sensitises nerves to cause pain, and stimulates local estrogen production that feeds further lesion growth (5-9)

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Challenges and Future Directions: A Rheumatologist Perspective These multiple effects make GLP-1 drugs an exciting prospect in autoimmune disease treatment