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2.6 Mitochondrial impairment causes reduction of enteroendocrine cells Intriguingly, deletion of the mitochondrial chaperone Hsp60 in murine colonocytes, triggering mitochondrial dysfunction and stress signaling, resembles the metabolic fingerprint of inflammation including up-regulation of Hk2 and Ddit4 , as well as down-regulation of Pck1 and Hmgcs2 (65)

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This technique prevents localized high concentrations that can cause aggregation

The application is based on a 64-week trial of 307 adults with obesity but without diabetes