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tesamorelin is the best imo (its FDA Approved for fat loss in HIV sufferers) but is hard to find and expensive

Disruption of nuclear envelope integrity as a possible initiating event in tauopathies

Yet another strategy is to use a molecular degrader of extracellular proteins, which links a target-binding unit (for instance binding to IgG, as with BHV-1300 [418]) to a motif that binds asialoglycoprotein receptors (ASGPR) to direct its targets to endolysosomal degradation in the liver [419, 420]

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