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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for several indications: type 2 diabetes management (under the brand names Ozempic and Rybelsus), chronic weight management in adults with obesity (BMI 30) or overweight (BMI 27) with at least one weight-related comorbidity (under the brand name Wegovy), and in adolescents aged 12 years and older with obesity

Research suggests that the ventromedial hypothalamus (VMH) plays a central role in leptin-induced glucose uptake in skeletal muscle, brown adipose tissue (BAT), and heart tissue