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In one published case, an active, lean-adjacent man lost about one-third of his total weight as muscle on 2.5 mg and recovered it after adding resistance training and increasing protein. This is a cautionary case, not an incidence estimate

Vegans and vegetarians are particularly at risk for B12 deficiency because plant-based foods do not naturally contain vitamin B12

Any turbidity signals aggregation or contamination and the vial should be discarded

"There's an ongoing discussion on the role of these B vitamins because of their positive effects on homocysteine, and because high levels of this amino acid in the blood can be a risk factor for heart disease, stroke, and blood clots," says John A

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