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Cellular levels of both -Glu-Cys and reduced GSH levels were significantly decreased (Supp Fig 3B), consistent with our hypothesis that the PfMRP1 mutant increases efflux of reduced GSH

Samples were prepared for mass spectrometry by lysing RBCs, reducing and alkylating proteins, and digesting them with trypsin

T lymphocytes CD4 + and CD8 + from HAM/TSP asymptomatic and symptomatic individuals presented a reduced ABCC1 expression and activity when compared to uninfected ones [34]

This gives CVS broader exposure to one of the hottest drug categories, while the company still talks about cost savings for plan sponsors