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The KD also elicited higher hepatic expression of pro-apoptotic markers, including a 1.8-fold increase in cleaved caspase-3 compared to high-sugar diets and a 2.1-fold elevation in the tumor suppressor protein p21

These changes reflect structural improvements from within rather than surface-level treatments

139,140 Besides SIRT3-mediated deacetylation, SIRT5-dependent desuccinylation improves ROS detoxification via increasing SOD1 activity

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By acting as a rate-limiter on gastric outflow, amylin spreads nutrient delivery over a longer window, lowering the peak