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Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in the Western hemisphere, affecting 20% to 30% of the adult population [1]

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FIGURE 6 12 Concluding remarks and future research In summary, metabolic dysfunction in T2DM affects insulin receptor signaling, inhibiting the PI3K-Akt cascade and enhancing GSK3 hyperactivity, NAD + depletion, and Sirt1/Sirt3 inactivation