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However, evidence shows that weight loss improves fibromyalgia pain severity in obese patients, and GLP-1 therapy produces sustained weight loss (15-22% over 68 weeks in trials) while improving insulin sensitivity and reducing inflammatory markersfactors that may support fibromyalgia management indirectly

However, these studies did not compare cohorts matched for age and BMI and, consequently, this could represent a chance association (37)

The main disadvantages of peptides are cost and availability

Final Thoughts Retatrutide has shown some of the most promising weight loss results reported in a Phase 3 clinical trial, with average weight loss reaching 28.3% at the highest dose

Better Mobility and Strength : Losing weight often leads to increased physical activity