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For patients focused on body composition (building lean mass while reducing body fat), some providers recommend pairing IGF-1 LR3 with a GLP-1 microdose protocol

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The IGF-1 signaling pathway has been implicated in lifespan control across multiple species, and IGF1 LR3 allows for controlled manipulation of this pathway to study its effects on cellular senescence, tissue maintenance, and age-related functional decline

| 2022 | International Journal of Molecular Sciences)