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"It was impressive to see that every dose of retatrutide resulted in clinically meaningful weight reduction for nearly all participants, and people with severe obesity on the highest dose lost on average 30 percent of their body weight over two years

As weight decreases and insulin sensitivity improves, blood glucose levels may drop, potentially requiring adjustments to other diabetes medications, particularly insulin or sulfonylureas

doi: 10.1016/j.jpsychires.2015.04.011

But some economists have warned that does not mean billions would be saved from having a large proportion of the population using weight loss drugs

However, its medicinal properties were soon recognised