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GHK-Cu applied to thigh skin for 12 weeks improved collagen production in 70% of the women treated, in contrast to 50% treated with the vitamin C cream and 40% treated with retinoic acid

This mechanism is implicated in diseases such as rheumatoid arthritis (RA), where oxidative modifications of proteins in the synovial fluid contribute to the autoimmune response [127, 128]

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Furthermore, several investigations suggested that ascorbate might directly repair H 2 O 2 -induced DNA alterations such as 8-oxoG and DNA strand break levels [173]