Statements Author contributions JZ, ZZ, MH and H-XH wrote the original draft
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Immune-based approaches Immune-based therapeutic strategies have been suggested for some patients with BD and MDD, although due to the biological and clinical heterogeneity of these complex disorders, this type of therapy could be considered as a part of personalized approach, beneficiating approximately one in three patients, according to previous studies [333]
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Research indicates that 5-MTHF increases plasma folate more effectively than folic acid, regardless of MTHFR mutations