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When healthy behaviors become part of a routine rather than a temporary program, long-term success becomes more achievable

Pollution and climate change, chemical compounds commonly used in industry and households, ecosystem changes, unhealthy diet, and stimulants, mainly alcohol, tobacco and e-cigarettes, may disrupt the epithelial barriers of the skin and mucosal surfaces

Mehta AN, Emmet JB, Emmett M

Perhaps this is because of the iron-overloaded environment in ectopic tissue cells [101]