Typically, healthcare providers prescribe a low starting dose of 2.5 mg before gradually increasing by 2.5 mg every four weeks until you reach a maintenance dose (5 mg, 10 mg, or 15 mg) thats effective for you
Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA
10 (2023): 102849, 10.1016/j.dsx.2023.102849
Conversely, M2 polarization is known to produce cytokines such as TGF-, CCL18, and IL-1Ra, which contribute to the reduction of inflammation
However, it is associated with dose limiting gastrointestinal side effects and should be avoided in any patient at risk of lactic acidosis (serum creatinine 1.4 ng/dL for females and 1.5 ng/dL for male, or heart failure exacerbation), patients receiving contrast dyes, or those with significant hepatic dysfunction