Rapid weight loss can temporarily shift estrogen production because estrogen is stored and synthesized in fat tissue
This process consumes large amounts of oxygen, which is converted into the highly-reactive superoxide radical O2- and H2O2 which together with other chemicals provide a toxic intra-phagosome environment able to kill a broad range of micro-organisms
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FIGURE 11 Molecular docking Ten targets (AKT1, TNF, SRC, EGFR, JUN, VEGFA, CND1, MAPK3, MAPK1, and CREB1) were chosen according to the results of the PPI network as the core targets of FRP for the treatment of AD
The reduction in circulating estrogen can affect the activation of estrogen receptors, potentially leading to low-estrogen diseases such as metabolic syndrome, cardiovascular diseases, and obesity