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This 5Me-THF depletion was coupled with blockade of de novo purine biosynthesis, resulting in an accumulation of endogenous AICAR (5-aminoimidazole-4-carboxamide ribonucleotide)

Navitoclaxs precursor, ABT737, a BH3 mimetic, prevents the interaction between anti-apoptotic and pro-apoptotic proteins, also leading to senescent cell apoptosis [105]

The interconversion of lactate and pyruvate, catalyzed by LDHA/B, is closely coupled to the NAD+/NADH redox pair, thereby modulating cellular redox balance in a context-dependent manner (84,85)

For example, the overexpression of Cu/Zn SOD was able to rescue dopaminergic neurons and diminishes locomotor disabilities in a mutant model for -synuclein overexpression [112]

Vitiligo is a skin condition characterized by loss of pigment and white patches appearing on the skin.