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Aggregation is commonly detected through broadened resonances in 1D spectra, abnormal diffusion behavior in DOSY experiments, and reduced TOCSY or NOESY cross-peak intensity

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Lee KJ , Moon JY , Choi HK , et al

The tradeoff is regulatory: compounded products are not FDA-approved for safety and efficacy the way brand Zepbound is, so active provider supervision matters more, not less

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