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In addition, astrocytes provide neurons with the amino acids required for GSH synthesis in a process that involves the export of GSH from astrocytes by the multidrug resistance protein 1, the extracellular processing of GSH via the astrocytic glutamyl transpeptidase to generate the dipeptide cysteinylglycine, and the extracellular cleavage of this dipeptide by the neuronal ectopeptidase aminopeptidase N

Therefore, GPX7 can maintain physiological homeostasis by enhancing the activity of GRP78 chaperone protein

Der Spiegel an reduziertem Glutathion innerhalb der Zellen ist fr das Energieniveau entscheidend