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Extrapolation from acute, controlled rodent injury models to chronic neurological conditions in humans is not supported by the present evidence base, and the preclinical evidence in non-musculoskeletal organ systems has not been independently replicated to the degree of the tendon work

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Aging is associated with high basal levels of circulating corticosteroids, although there is not always a correlation between plasma ACTH and corticosteroids (233-235)