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Although MM rarely shows BRCA mutations, the significantly high level of structure variation indicates the deficiency of homologous recombination repair (HRR) capacity, which makes MM potentially responsive to PARP inhibition

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Dual GLP-1/GCG agonists such as mazdutide and survodutide are currently in phase 3 clinical trials as obesity treatments, with pemvidutide having recently completed phase 2 trials