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Because TB-500 distributes systemically regardless of injection site, there is no clinical requirement to inject near the injury

The interplay of local (within the diseased liver) and systemic inflammation, stemming from portal hypertension and alterations in the gut microbiome, alongside heightened levels of circulating cytokines, disrupts hepatic vagal neurogenic responses and impacts cerebral endothelial cells, giving rise to neuroinflammation

However, for many many patients one needs to be aware that the dose is often well under 400 mg daily

These reactions are typically transient, resolving within hours to a day or two

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