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Both groups receiving SHR-5 demonstrated statistically significant enhancements in overall depressive symptoms, sleep disturbances, emotional dysregulation, and somatic complaints, whereas the placebo cohort exhibited no such clinical improvements

The primary preclinical evidence comes from mouse studies showing reduced body weight and adipose mass in diet-induced obese mice (2018), improved grip strength in aged mice (2024), and beneficial microbiome changes when combined with caloric restriction (2022)

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