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Description

Patients with Mitochondrial Disease: There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase (POLG) gene (e.g

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BPC-157 promotes tendon healing at the cellular level by activating fibroblast migration, proliferating tenocyte populations, and upregulating growth factor receptor expression at the injury site

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The finding of increased risk with AEDs of varying mechanisms of action and across a range of indications suggests that the risk applies to all AEDs used for any indication

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