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Doses up to 600 mg were generally well-tolerated with no clinically significant abnormalities in blood pressure or heart rate, no observed skin pigmentation, and no significant changes to adrenal, urinary or hematology panels

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[DOI] [PubMed] [Google Scholar] 4.Seiwerth S., Milavic M., Vukojevic J., Gojkovic S., Krezic I., Vuletic L.B., Pavlov K.H., Petrovic A., Sikiric S., Vranes H., et al