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It inhibits the cysteine/glutamate antiporter system Xc-, thereby revoking cysteine import and thus reducing glutathione synthesis
Studies have shown that cisplatin treatment leads to iron ion accumulation, thereby inducing ferroptosis in ovarian tissues, and the use of Fer-1 can inhibit cisplatin-induced ovarian damage and granulosa cell death [65]
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The other gene (symbol: TKTL2) is located on chromosome 4q32.2