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Diabetes medications Research has shown that Actos (pioglitazone), or combination drugs that contain pioglitazone, a diabetes medication, may decrease birth control pill effectiveness

In a series of trials, this same research group found that use of lithium reduced PKC in rat frontal cortex and hippocampus, suggesting that PKC inhibition may have antimanic efficacy

It is uncertain whether their effects are similar in non-obese or less-obese populations, or whether benefits extend to other disease subtypes such as hand OA

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Many patients administer both on the same day for convenience, while others space them throughout the week based on personal preference and symptom management