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4F, in si-EAAT3 and si-P65 cells, despite being in a state of oxidative stress, TEM revealed that mitochondrial morphology remained largely normal, with only a slight increase in electron density and occasional mitochondrial membrane rupture, which appeared to be within the cells adaptive capacity

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Graphical Abstract Similar content being viewed by others Introduction Professor Ernest Starling proposed the idea of using a gut hormone for the treatment of diabetes in London in the early 1900s and this idea was first tested by administering gut extracts to individuals with the disease [1]

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