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Das S, Owen KA, Ly KT, Park D, Black SG, Wilson JM, et al

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doi: 10.1007/s00125-011-2304-4 58 WilkesJJLloydDJGekakisN

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Mutant presenilins 1 and 2 disrupt mitochondrial calcium signalling, which leads to decreased ATP production, increased ROS emission, and cell death [78]

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Several studies have shown that ROS affects the cell cycle, leading to cell damage and apoptosis, a process that leads to many types of cancer [2]

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